Macromolecular Proton Fraction (MPF): Quantitative Myelin Mapping Technique for Neuroscience

Macromolecular Proton Fraction (MPF) mapping is a recently developed magnetic resonance imaging (MRI) technology enabling quantitative assessment of myelination in the nervous system. This site serves as a Resource for widespread distribution and implementation of the fast MPF mapping technology under support of the National Institute of Neurological Disorders and Stroke (NINDS) High Impact Neuroscience Research Resource Grant “Quantitative myelin mapping in vivo for clinical and pre-clinical MRI”.


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Researchers from the University of Washington Institute for Learning & Brain Sciences employed MPF mapping to assess correlations between myelination and language experience in two-year-old children.
Our team with colleagues from the University of Wisconsin–Madison and Polytechnique Montreal will carry out a two-hour teaching session on the software tools and protocol design for MPF mapping.