Anna Naumova

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Anna V. Naumova, Ph.D.

Anna Naumova graduated with honors the Tomsk State University (Russia) with an MS in biology and applied informatics; then she obtained PhD from the Institute of Cardiology (Tomsk, Russia) and the Doctor Habilitatus degree from the Moscow State University (Russia). Currently, Dr. Naumova is a Research Associate Professor at the Department of Radiology, UW Medicine. She has a long-standing interest in biomedical imaging of cardiac regeneration. Dr. Naumova is collaborating with other UW faculties in development of non-invasive imaging techniques to bridge the gap between cardiac therapies and subsequent health outcome. In collaboration with Dr. Yarnykh, Dr. Naumova is developing cardiac MRI technique based on the endogenous macromolecular contrast mechanisms. The ultimate goal of Dr. Naumova’s research is to bring new quantitative imaging technologies to address the unmet needs of the regenerative medicine, myocardial tissue characterization and heart failure treatment outcome with transplanted cells.

Selected publications:

1. Naumova AV, Weiss RG, Chacko VP.  Regulation of Murine Myocardial Energy Metabolism During Adrenergic Stress Studied by In Vivo Phosphorus-31 NMR Spectroscopy. Am J Physiol Heart Circ Physiol  2003; 285(5): H1976-1979. PMID: 12881208.

2. Naumova AV, Chacko VP, Ouwerkerk R, Stull L, Marban E, Weiss RG. Xanthine Oxidase Inhibitors Improve Energetics and Function Following Infarction in the Failing Mouse Heart. Am J Physiol Heart Circ Physiol 2006; 290: H837-H843.  PMID: 16183726.

3. Laflamme MA, Chen KY, Naumova AV, Muskheli V, Fugate JA, Dupras SK, Xu C, Hassanipour M, Police S, O’Sullivan C, Collins L, Minami E, Gill E.A, Ueno S, Yuan C, Gold J, Murry CE.  Delivery of Human Embryonic Stem Cell Cardiomyocytes in Pro-Survival Factors Enhances the Function of Infarcted Hearts. Nature Biotechnol, 2007, 25: 1015–1024.

4. Naumova AV, Reinecke H, Yarnykh V, Deem J, Yuan C, Murry CE.  Ferritin Overexpression for Noninvasive MRI-Based Tracking of Stem Cells Transplanted into the Heart. J Mol Imaging, 2010, 9 (4): 201-210. PMID: 20643023. PMC4082401.

5. Naumova AV, Yarnykh VL, Balu N, Reinecke H, Murry CE, Yuan C. Quantification of MRI Signal of Transgenic Grafts Overexpressing Ferritin in Murine Myocardial Infarcts. NMR Biomed. 2012; 25(10): 1187-1195. PMID: 22362654. PMCID: PMC3389131.

6. Kerwin WS, Naumova AV, Storb R, Tapscott S, Wang Z.  Mapping contrast agent uptake and retention in CMRI studies of myocardial perfusion: Case control study of dogs with Duchenne Muscular Dystrophy. Int J Cardiovasc Imaging, 2013 Apr;29(4):819-26. PMCID: PMC3594362.

7. Naumova AV, Balu N, Yarnykh VL, Reinecke H, Murry CE, Yuan C. MRI Tracking of Graft Survival in the Infarcted Heart: Iron Oxide Particles vs. Ferritin Overexpression Approach. J Cardiovasc Pharmacol Ther. 2014 Mar 30;19(4):358-367. PMCID: PMC4185000.

8. Naumova AV, Modo M, Moore A, Murry CE, Frank JA. Clinical imaging to track cell fate and function in regenerative medicine. Invited review. Nature Biotechnol, 2014 Aug 5;32(8):804-818. PMCID: PMC4164232.  Response to cardiac regeneration validated. Nature Biotechnol, 2015 Jun;33(6):587. PMID: 26057970.

9. Naumova AV, Akulov AE, Khodanovich MY, Yarnykh VL. High-resolution three-dimensional macromolecular proton fraction mapping for quantitative neuroanatomical imaging of the rodent brain in ultra-high magnetic fields.  Neuroimage, 2017 Feb 15;147:985-993. PMID: 27646128.

10.  Liu YW, Chen B, Yang X, et al. Human ESC-Derived Cardiomyocytes Restore Function in Infarcted Hearts of Non-Human Primates. Nature Biotechnol. 2018, 36 (7): 597–605.