Macromolecular Proton Fraction (MPF): Quantitative Myelin Mapping Technique for Neuroscience

Age-Related Decline in Brain Myelination: Quantitative Macromolecular Proton Fraction Mapping, T2-FLAIR Hyperintensity Volume, and Anti-Myelin Antibodies Seven Years Apart.

Khodanovich M, Svetlik M, Naumova A, Kamaeva D, Usova A, Kudabaeva M, Anan'ina T, Wasserlauf I, Pashkevich V, Moshkina M, Obukhovskaya V, Kataeva N, Levina A, Tumentceva Y, Yarnykh V.

Biomedicines. 2023 Dec 27;12(1):61. doi: 10.3390/biomedicines12010061.

PMID: 38255168 Free article

 

​​​​Developmental and regional dependence of macromolecular proton fraction and fractional anisotropy in fixed brain tissue.

Drobyshevsky A, Synowiec S, Goussakov I, Yarnykh V.

NMR Biomed. 2023 Jul;36(7):e4915. doi: 10.1002/nbm.4915.

Epub 2023 Mar 22.PMID: 36895100

 

Temporal trajectories of normal myelination and axonal development assessed by quantitative macromolecular and diffusion MRI: Ultrastructural and immunochemical validation in a rabbit model.

Drobyshevsky A, Synowiec S, Goussakov I, Lu J, Gascoigne D, Aksenov DP, Yarnykh V.

Neuroimage. 2023 Apr 15;270:119974. doi: 10.1016/j.neuroimage.2023.119974.

Epub 2023 Feb 26.PMID: 36848973 Free PMC article

 

Language Experience during Infancy Predicts White Matter Myelination at Age 2 Years.

Huber E, Corrigan NM, Yarnykh VL, Ferjan Ramírez N, Kuhl PK.

J Neurosci. 2023 Mar 1;43(9):1590-1599. doi: 10.1523/JNEUROSCI.1043-22.2023. Epub 2023 Feb 6.PMID: 36746626

 

Language input in late infancy scaffolds emergent literacy skills and predicts reading related white matter development.

Weiss Y, Huber E, Ferjan Ramírez N, Corrigan NM, Yarnykh VL, Kuhl PK.

Front Hum Neurosci. 2022 Nov 15;16:922552. doi: 10.3389/fnhum.2022.922552. eCollection 2022.

PMID: 36457757 Free PMC article

 

Brain myelination at 7 months of age predicts later language development.

Corrigan NM, Yarnykh VL, Huber E, Zhao TC, Kuhl PK.

Neuroimage. 2022 Nov;263:119641. doi: 10.1016/j.neuroimage.2022.119641.

Epub 2022 Sep 25.PMID: 36170763 Free PMC article

 

Development of executive function-relevant skills is related to both neural structure and function in infants.

Zhao TC, Corrigan NM, Yarnykh VL, Kuhl PK.

Dev Sci. 2022 Nov;25(6):e13323. doi: 10.1111/desc.13323.

Epub 2022 Sep 27.PMID: 36114705

 

​Macromolecular Proton Fraction as a Myelin Biomarker: Principles, Validation, and Applications.

Kisel AA, Naumova AV, Yarnykh VL.

Front Neurosci. 2022 Feb 9;16:819912. doi: 10.3389/fnins.2022.819912. eCollection 2022.

PMID: 35221905 Free PMC Article Review.

  

Data-Driven Retrospective Correction of B1 Field Inhomogeneity in Fast Macromolecular Proton Fraction and R1 Mapping.

Yarnykh VL.

IEEE Trans Med Imaging. 2021 Dec;40(12):3473-3484. doi: 10.1109/TMI.2021.3088258.

Epub 2021 Nov 30.PMID: 34110989 Free PMC article

 

Global hypomyelination of the brain white and gray matter in schizophrenia: quantitative imaging using macromolecular proton fraction.

Smirnova LP, Yarnykh VL, Parshukova DA, Kornetova EG, Semke AV, Usova AV, Pishchelko AO, Khodanovich MY, Ivanova SA.

Transl Psychiatry. 2021 Jun 30;11(1):365. doi: 10.1038/s41398-021-01475-8.

PMID: 34226491 Free PMC Article

 

Long-term monitoring of chronic demyelination and remyelination in a rat ischemic stroke model using macromolecular proton fraction mapping.

Khodanovich MY, Gubskiy IL, Kudabaeva MS, Namestnikova DD, Kisel AA, Anan'ina TV, Tumentceva YA, Mustafina LR, Yarnykh VL.

J Cereb Blood Flow Metab. 2021 Nov;41(11):2856-2869. doi: 10.1177/0271678X211020860.

Epub 2021 Jun 9.PMID: 34107787

 

Myelin development in cerebral gray and white matter during adolescence and late childhood.

Corrigan NM, Yarnykh VL, Hippe DS, Owen JP, Huber E, Zhao TC, Kuhl PK.

Neuroimage. 2021 Feb 15;227:117678. doi: 10.1016/j.neuroimage.2020.117678.

PMID: 33359342 Free Article

 

Three-dimensional fast single-point macromolecular proton fraction mapping of the human brain at 0.5 Tesla.

Anisimov NV, Pavlova OS, Pirogov YA, Yarnykh VL.

Quant Imaging Med Surg. 2020 Jul;10(7):1441-1449. doi: 10.21037/qims-19-1057.

PMID: 32676363 Free PMC Article

 

Scan-Rescan Repeatability and Impact of B0 and B1 Field Nonuniformity Corrections in Single-Point Whole-Brain Macromolecular Proton Fraction Mapping.

Yarnykh VL, Kisel AA, Khodanovich MY.

J Magn Reson Imaging. 2020;51(6):1789-1798. doi:10.1002/jmri.26998

PMID: 31737961 Free PMC Article

 

Quantitative Imaging of White and Gray Matter Remyelination in the Cuprizone Demyelination Model Using the Macromolecular Proton Fraction.

Khodanovich M, Pishchelko A, Glazacheva V, Pan E, Akulov A, Svetlik M, Tyumentseva Y, Anan'ina T, Yarnykh V.

Cells. 2019 Oct 5;8(10). pii: E1204. doi: 10.3390/cells8101204.

PMID: 31590363 Free PMC Article

 

Direct comparison between apparent diffusion coefficient and macromolecular proton fraction as quantitative biomarkers of the human fetal brain maturation.

Korostyshevskaya AM, Prihod'ko IY, Savelov AA, Yarnykh VL.

J Magn Reson Imaging. 2019 Jul;50(1):52-61. doi: 10.1002/jmri.26635. Epub 2019 Jan 11.

PMID: 30635965 Free PMC Article

 

Immediate and delayed decrease of long term potentiation and memory deficits after neonatal intermittent hypoxia.

Goussakov I, Synowiec S, Yarnykh V, Drobyshevsky A.

Int J Dev Neurosci. 2019 May;74:27-37. doi: 10.1016/j.ijdevneu.2019.03.001. Epub 2019 Mar 9.

PMID: 30858028 Free PMC Article

 

Congenital medulloblastoma: Fetal and postnatal longitudinal observation with quantitative MRI.

Korostyshevskaya AM, Savelov AA, Papusha LI, Druy AE, Yarnykh VL.

Clin Imaging. 2018 Nov - Dec;52:172-176. doi: 10.1016/j.clinimag.2018.06.001. Epub 2018 Jun 7.

PMID: 30096555

 

Quantitative assessment of demyelination in ischemic stroke in vivo using macromolecular proton fraction mapping.

Khodanovich MY, Kisel AA, Akulov AE, Atochin DN, Kudabaeva MS, Glazacheva VY, Svetlik MV, Medvednikova YA, Mustafina LR, Yarnykh VL.

J Cereb Blood Flow Metab. 2018 May;38(5):919-931. doi: 10.1177/0271678X18755203. Epub 2018 Jan 26. Erratum in: J Cereb Blood Flow Metab. 2018 Jan 1;:271678X18761472.

PMID: 29372644  Free PMC Article

 

Microbiota influence the development of the brain and behaviors in C57BL/6J mice.

Lu J, Synowiec S, Lu L, Yu Y, Bretherick T, Takada S, Yarnykh V, Caplan J, Caplan M, Claud EC, Drobyshevsky A.

PLoS One. 2018 Aug 3;13(8):e0201829. doi: 10.1371/journal.pone.0201829. eCollection 2018.

PMID: 30075011 Free PMC Article

 

Quantitative Assessment of Normal Fetal Brain Myelination Using Fast Macromolecular Proton Fraction Mapping.

Yarnykh VL, Prihod'ko IY, Savelov AA, Korostyshevskaya AM.

AJNR Am J Neuroradiol. 2018 Jul;39(7):1341-1348. doi: 10.3174/ajnr.A5668. Epub 2018 May 10.

PMID: 29748201 Free Article

 

Iron-Insensitive Quantitative Assessment of Subcortical Gray Matter Demyelination in Multiple Sclerosis Using the Macromolecular Proton Fraction.

Yarnykh VL, Krutenkova EP, Aitmagambetova G, Repovic P, Mayadev A, Qian P, Jung Henson LK, Gangadharan B, Bowen JD.

AJNR Am J Neuroradiol. 2018 Apr;39(4):618-625. doi: 10.3174/ajnr.A5542. Epub 2018 Feb 8.

PMID: 29439122  Free PMC Article

 

Histological validation of fast macromolecular proton fraction mapping as a quantitative myelin imaging method in the cuprizone demyelination model.

Khodanovich MY, Sorokina IV, Glazacheva VY, Akulov AE, Nemirovich-Danchenko NM, Romashchenko AV, Tolstikova TG, Mustafina LR, Yarnykh VL.

Sci Rep. 2017 Apr 24;7:46686. doi: 10.1038/srep46686.

PMID: 28436460 Free PMC Article

 

High-resolution three-dimensional quantitative map of the macromolecular proton fraction distribution in the normal rat brain.

Naumova AV, Akulov AE, Khodanovich MY, Yarnykh VL.

Data Brief. 2016 Dec 5;10:381-384. doi: 10.1016/j.dib.2016.11.066. eCollection 2017 Feb.

PMID: 28018953 Free PMC Article

 

High-resolution three-dimensional macromolecular proton fraction mapping for quantitative neuroanatomical imaging of the rodent brain in ultra-high magnetic fields.

Naumova AV, Akulov AE, Khodanovich MY, Yarnykh VL.

Neuroimage. 2017 Feb 15;147:985-993. doi: 10.1016/j.neuroimage.2016.09.036. Epub 2016 Sep 17.

PMID: 27646128 Free PMC Article

 

Fast macromolecular proton fraction mapping of the human liver in vivo for quantitative assessment of hepatic fibrosis.

Yarnykh VL, Tartaglione EV, Ioannou GN.

NMR Biomed. 2015 Dec;28(12):1716-25. doi: 10.1002/nbm.3437. Epub 2015 Oct 27.

PMID: 26503401 Free PMC Article

 

Time-efficient, high-resolution, whole brain three-dimensional macromolecular proton fraction mapping.

Yarnykh VL.

Magn Reson Med. 2016 May;75(5):2100-6. doi: 10.1002/mrm.25811. Epub 2015 Jun 22.

PMID: 26102097 Free PMC Article

 

Removal of cerebrospinal fluid partial volume effects in quantitative magnetization transfer imaging using a three-pool model with nonexchanging water component.

Mossahebi P, Alexander AL, Field AS, Samsonov AA.

Magn Reson Med. 2015 Nov;74(5):1317-26. doi: 10.1002/mrm.25516. Epub 2014 Nov 13.

PMID: 25394181 Free PMC Article

 

Fast whole-brain three-dimensional macromolecular proton fraction mapping in multiple sclerosis.

Yarnykh VL, Bowen JD, Samsonov A, Repovic P, Mayadev A, Qian P, Gangadharan B, Keogh BP, Maravilla KR, Jung Henson LK.

Radiology. 2015 Jan;274(1):210-20. doi: 10.1148/radiol.14140528. Epub 2014 Sep 10.

PMID: 25208343 Free PMC Article

 

Paclitaxel improves outcome from traumatic brain injury.

Cross DJ, Garwin GG, Cline MM, Richards TL, Yarnykh V, Mourad PD, Ho RJ, Minoshima S.

Brain Res. 2015 Aug 27;1618:299-308. doi: 10.1016/j.brainres.2015.06.006. Epub 2015 Jun 15.

PMID: 26086366 Free PMC Article

 

Neuroimaging, behavioral, and psychological sequelae of repetitive combined blast/impact mild traumatic brain injury in Iraq and Afghanistan war veterans.

Petrie EC, Cross DJ, Yarnykh VL, Richards T, Martin NM, Pagulayan K, Hoff D, Hart K, Mayer C, Tarabochia M, Raskind MA, Minoshima S, Peskind ER.

J Neurotrauma. 2014 Mar 1;31(5):425-36. doi: 10.1089/neu.2013.2952.

PMID: 24102309 Free PMC Article

 

Fast macromolecular proton fraction mapping from a single off-resonance magnetization transfer measurement.

Yarnykh VL.

Magn Reson Med. 2012 Jul;68(1):166-78. doi: 10.1002/mrm.23224. Epub 2011 Dec 21.

PMID: 22190042 Free PMC Article