Macromolecular Proton Fraction (MPF): Quantitative Myelin Mapping Technique for Neuroscience
The study quntified the rates of myelin loss in various brain structures associated with normal ageing in normal adults in the age range 33-60 years over a seven-year time interval. The greatest decrease in MPF was observed for the frontal white matter (2–5%), genu of the corpus callosum (4.0%), and caudate nucleus (5.9%), which translates in average myelin loss rates of 0.3-0.8% per year.