Macromolecular Proton Fraction (MPF): Quantitative Myelin Mapping Technique for Neuroscience

Editor's Choice article in Biomedicines

The study quntified the rates of myelin loss in various brain structures associated with normal ageing in normal adults in the age range 33-60 years over a seven-year time interval. The greatest decrease in MPF was observed for the frontal white matter (2–5%), genu of the corpus callosum (4.0%), and caudate nucleus (5.9%), which translates in average myelin loss rates of 0.3-0.8% per year.

Age-Related Decline in Brain Myelination: Quantitative Macromolecular Proton Fraction Mapping, T2-FLAIR Hyperintensity Volume, and Anti-Myelin Antibodies Seven Years Apart. Khodanovich M, Svetlik M, Naumova A, Kamaeva D, Usova A, Kudabaeva M, Anan'ina T, Wasserlauf I, Pashkevich V, Moshkina M, Obukhovskaya V, Kataeva N, Levina A, Tumentceva Y, Yarnykh V. Biomedicines. 2023;12(1):61.