Macromolecular Proton Fraction (MPF): Quantitative Myelin Mapping Technique for Neuroscience

MPF mapping Symposium at ISMRM 2021 went a great success

The Member-Initiated Symposium “Macromolecular Proton Fraction (MPF): An Emerging Quantitative Myelin Biomarker for Preclinical & Clinical Studies” was held within the program of the online ISMRM Annual Meeting and Exhibition (May 15-20, 2021). The Symposium was organized by the Resource team (V. Yarnykh and A, Naumova) as a live online event, which occurred on May 18, 2021 and included four invited scientific lectures followed by the questions and answers session with the total duration of two hours. The Symposium program included the following lectures: “Magnetization Transfer Contrast - Historical Perspective” by Greg Stanisz, PhD (Sunnybrook Research Institute, Toronto, Canada); “Fast Macromolecular Proton Fraction Mapping: Physical Principles and Clinical Applications” by Alexey Samsonov, PhD (University of Wisconsin – Madison, Madison, WI, USA); “Histological validation and preclinical applications of MPF as a myelin biomarker” by Marina Khodanovich, PhD (Tomsk State University, Tomsk, Russia); and “High-resolution 3D macromolecular proton fraction mapping of the human brain: a new tool for quantitative neuroscience” by Neva Corrigan, PhD (University of Washington, Seattle, WA, USA). The lectures described the principles of quantitative MT imaging, the technical background of the fast MPF mapping method and its technical progress over past years, summarized the histological evidence supporting the utility of MPF as a myelin biomarker, reviewed recent neuroscience applications of high-resolution MPF maps, and provided a number of practical advices regarding the method implementation and usage.

The Symposium program is available online at The full Symposium video recording is available to the Meeting participants at The Syllabus of the Symposium lectures is available on our website: The Symposium went a great success with the total of 299 participants representing 25 countries. The lectures promoted active discussion among participants with more than 60 entries in the online Symposium chat including questions, answers, and attendees’ opinions.

Greetings from the  Speakers and Moderators!